KPV
Lys-Pro-Val · α-MSH(11-13)
Le KPV (Lys-Pro-Val) est le tripeptide C-terminal de l'α-MSH. Il est étudié in vitro et en modèle préclinique pour la modulation de la voie inflammatoire NF-κB et son absorption via le transporteur PepT1. Réactif destiné exclusivement à la recherche en laboratoire — non destiné à la consommation humaine.
En bref
- Classe
- Tripeptide (3 aa)
- Origine
- Fragment C-terminal de l'α-MSH
- Forme
- Lyophilisée (poudre)
- Statut
- Research Use Only
Axes de recherche documentés
Bibliothèque d'études
Tous les résultats sur PubMedDissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides.
Getting SJ, et al. · The Journal of pharmacology and experimental therapeutics · 2003
Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease.
Kannengiesser K, et al. · Inflammatory bowel diseases · 2008
Inflammation-triggered self-immolative conjugates enable oral peptide delivery by overcoming gastrointestinal barriers.
Cheng J, et al. · Science advances · 2026
Transdermal Iontophoretic Delivery of Lysine-Proline-Valine (KPV) Peptide Across Microporated Human Skin.
Pawar K, et al. · Journal of pharmaceutical sciences · 2017
A new era of doping? Use of peptide and peptide-analog drugs in recreational and professional sport and bodybuilding: a critical review.
Coutinho LFD, et al. · The Journal of sports medicine and physical fitness · 2026
Terminal signal: anti-inflammatory effects of α-melanocyte-stimulating hormone related peptides beyond the pharmacophore.
Brzoska T, et al. · Advances in experimental medicine and biology · 2010
PepT1-targeted nanodrug based on co-assembly of anti-inflammatory peptide and immunosuppressant for combined treatment of acute and chronic DSS-induced ColitiS.
Zhang D, et al. · Frontiers in pharmacology · 2024
The neuroimmunomodulatory peptide alpha-MSH.
Ichiyama T, et al. · Annals of the New York Academy of Sciences · 2000
Critical role of PepT1 in promoting colitis-associated cancer and therapeutic benefits of the anti-inflammatory PepT1-mediated tripeptide KPV in a murine model.
Viennois E, et al. · Cellular and molecular gastroenterology and hepatology · 2016
KPV and RAPA Self-Assembled into Carrier-Free Nanodrugs for Vascular Calcification Therapy.
Zhang L, et al. · Advanced healthcare materials · 2024
PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation.
Dalmasso G, et al. · Gastroenterology · 2008
Self-Cross-Linked Hydrogel of Cysteamine-Grafted γ-Polyglutamic Acid Stabilized Tripeptide KPV for Alleviating TNBS-Induced Ulcerative Colitis in Rats.
Sun J, et al. · ACS biomaterials science & engineering · 2021
Résultats récupérés en direct depuis PubMed (NCBI). Littérature de recherche uniquement — aucun conseil médical.
Peptides de recherche — Research Use Only
- Non destinés à la consommation humaine
- Non destinés au diagnostic, au traitement ou à la prévention d'une maladie